[5]Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5 deiodinase in lung cancer with peripheral lung tissues. But what can be done for patients who are at low Are you sure you want to block this member? Unfortunately, it's quite typical. [4], More recently DI activity in lung cancer was found to be lower than in peripheral lung tissue.[5]. I have always found this condition a riddle. They compared sale of, "However, the impression we get from our experience, Health, Studies, Supps & Pharmaceuticals. Iodine - and the lack of it - is implicated in breast cancer, after all. Also, what is oxidised stress??? I think there is always a lot of confusion with cause and cure. I am having a lot of trouble making any sense of this study. I am going to go for a walk with my dog :)). I've been on synthroid for 20+ years, scary. As you know, I appreciate people posting links that help us learn more about lung cancer, too. Obesity epidemic caused by EMF exposures in the ho War on Health - The FDA's Cult of Tyranny. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as hypothyroidism? For more information, please see our They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. The first blood test typically done to diagnose hypothyroidism measures the level of thyroid-stimulating hormone (TSH) in the blood. [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. Scan this QR code to download the app now. Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. Even in the mildest form, hypothyroidism affects the heart. My Endocrinologist was, and continues to be, open about the elevated risk for thyroid cancer due to the multiple. If the results show that TSH is high and T-4 is low, then the diagnosis . Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. 2002 Feb ;25(2):106-9. [13] Hollowell JG, Staehling NW, Flanders WD. Marketed as superior to traditional glandular forms extracted from pigs (whose endocrine glands are far more bioidentical than any other animal we know of) due to the dose-to-dose standardization of the so-called active ingredient T4 versus the natural variations in hormone concentrations found in the real thing, which incidentally contains a wide range of additional hormones including T1, T2, T3, all of which are vitally important. Assessment of oxidative stress and its balance has not been taken into consideration up to now as it should be. [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. [5] Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5' deiodinase in lung cancer with peripheral lung tissues. (February 2002). Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. I wish I could say that my story was atypical. [11] Wan J, Chai H, Yu Z, Ge W, Kang N, Xia W, Che Y: H1F-1 on angiogenic potential in human small cell carcinoma. [6] Venditti P, Di Stefano L, Di Meo S: Oxidative stress in cold induced hyperthyroid state. Very interesting article, thank you for sharing. by D.ap Tue Feb 21, 2017 10:40 am, Powered by phpBB Forum Software phpBB Limited. I have posted the link, so you can see if it has any merit. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. That's all. However, I do not believe it was out of the blue now. This relatively symptom-free reservoir of 'hypothyroid' cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. Eventually, the decline in thyroid hormone production can result in any of the following: Fatigue and sluggishness. This is a horrible disease that ravages the body. LOL. Hashimoto's disease progresses slowly over the years. Post I have sent the link that I read today. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. Those with the greatest risk of developing thyroid disorders are women who have a family history of the disease. Correlation is when two things seem to happen at the same time, in the same place, and/or in the same population. Ultimately, this latest Italian study is bringing to our attention one of what is likely a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. Allthewebsites Directory - A niche web directory offering website promotion and other webmaster resources. However, I'm learning from science writer friends, researchers, and medical professionals that (1) some studies are better designed and carried out than others, and (2) some journalists are more careful about drawing conclusions and writing sensational headlines than others. View the data on our Hypothyroidism Research page. Or, simply look at what the young-adult,T-score based definition of osteoporosis and osteopeniahas done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. You must log in or register to reply here. According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called subclinical hypothyroidism only detected via blood work. The authors expanded on their findings further: However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. In fact, it is the high levels of T4 that make them more susceptible to cancer. Why not simply call it selenium deficiency? Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the low thyroid, why call chemical poisoning hypothyroidism? Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Posted on: Monday, August 12th 2013 at 7:15 am Written By: Sayer Ji, Founder A new study has. 2013 May ;98(5):1982-90. JavaScript is disabled. Asesora y Consultora Web3 para empresas. The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. J. Clin. Results indicate that treatment with levothyroxine was linked with significantly increased mortality (hazard ratio = 1.19). [4] Ratcliffe JG, Stack BH, Burt RW, Radcliffe WA, Spilg WG, Cuthbert J, Kennedy RS: Thyroid function in lung cancer. Clin Cancer Res 2011, 30:77. Article published in Wakeup-World.Com. For a better experience, please enable JavaScript in your browser before proceeding. Objectives: To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism. Nope. If You Don't Want Older Bones, Don't Be Low In Vit Background Mortality Rate for Vaccines, or Pseudo Everything You Ever Wanted to Know About Black Seeds. Yes, lung cancer patients can have these symptoms, but so do patients who have other cancers. J Endocrinol Invest. Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-l Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, Iodine Supplementation Support by VWT Team. New Cholesterol Drug Guaranteed to Prematurely Kil Beware the Walgreens travel vaccination scam. Endocrinology 2008, 149:22412250. In the United States, autoimmune thyroid disease (Hashimoto thyroiditis) is the most common cause of hypothyroidism, but globally lack of iodine in the diet is the most common cause. El almacenamiento o acceso tcnico que se utiliza exclusivamente con fines estadsticos annimos. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. I'm just saying the evidence presented in this article isn't very strong, and more study is needed to show Synthroid causes lung cancer. I invite those interested to read it and perhaps we can have a discussion on this study. Cookie Notice Why not simply call it selenium deficiency? Medical Authoritys System Kills: FDA-Approved Dru Cognitive Impairment, Memory Loss and Alzheimer's Soy Lecithin: How It Negatively Affects Your Healt Cannabis Oil Cures Cancer -Lincoln Horsley's Story New Information Dissolves Illusions About Vaccines Grounding Helps Thin Dangerously Thick Blood and F Tart Cherries Relieve Osteoarthritis Pain, Lieberman's Massive Connections To Big Pharma, Utopian 'Harvest Your Own' Groceries Coming Up. But that's just me. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. Thyroid disease is a major public health concern worldwide. They found no significant correlation between T4 sales and breast, colorectal and gastric cancers, but did find a significant correlation for lung cancer (p < 0.05) corrected for smoking and age. Modern Medicine, Part I: How Healing Illness Becam Is your body getting too acidic? [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. Brit Med J 1978, 1:210212. Not what people like me are saying. Compression of the trachea, which may be positional, can occur with nodular goiters and thyroid cancer, and the latter can metastasize to the lungs. A place for patients and relatives. Overtreatment, of course, is the hallmark danger of overdiagnosis. The reality is that most cases of hypothyroidism today are diagnosed in populations who are experiencing a combination of basic nutritional deficiencies and chemical exposures, or who are simply going through a temporary down-cycle in thyroid function following a natural change, such as the natural postpartum drop that occurs in women after giving birth. There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. arizona lockdown status today; tiktok unblocked from school; samantha and savannah concepcion [14] K A Woeber. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. Lung cancer survivors support group and discussion community, http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-lung-cancers?utm_source=www.GreenMedInfo.com&utm_campaign=2189ddd3c1-Greenmedinfo&utm_medium=email&utm_term=0_193c8492fb-2189ddd3c1-87046221. ", Orsomeone posts something about, say a diet or supplement and them some people think they are something it "Cures lung cancer.". Cancer-related fatigue (CRF) is common in lung cancer survivors and can occur at any point in the care continuum. Angiology 2000, 51:S65S68. Another recently approved drug is tepotinib (Tepmetko). One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore back up causing excessive T4 activity, i.e. [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: Recently T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. As a never smoker I truly wish I smoked so I could just say that's why I got this. Due to excessive bot signups along with nefarious actors we are limiting forum registration. CRF encompasses physical, emotional, and/or cognitive tiredness; is related to cancer or cancer treatments; and interferes with multiple dimensions of health-related quality of life (1-3).CRF is poorly understood, underrecognized, and undertreated. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low . I don't think so. It is worth reading. Once I got on the medication, the symptoms disappeared. Tokushima J Exp Med 1991, 38:2535. Garlic Beats Drug in Detoxifying Lead Safely From How Yoga and Acupuncture Enhance HealthNew Resear Health Nuts: Seeds And Nuts You Should Eat Every Day. PMID: 11929079, [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. Ultimately, this Italian study brings further attention to one of a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. Overtreatment, of course, is the hallmark danger of overdiagnosis. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic 'self-fulfilling prophecy' if you will. She wrote about a product called Thyrtophin PMG. A couple of caveats to note in this study: The authors found a statistical correlation between the increase in sales of the thyroid medicine Synthroid, and an increase in lung cancer in Italy. The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. I have so much to say about this I could write a book. I am convinced that my lung cancer is related to the thyroid/auto immune issues I've had for years. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. Thyroid dysfunction after immune checkpoint inhibitor treatment in a single-center Chinese cohort: a retrospective study I think part of sharing information here on Inspire is the discussions about the articles we share. Patient characteristics. elevated TSH, without actually improving the overall physiological situation, nor the patient's subjective experience of well being. If I can help someone, fine. The increasingly global medical-industrial complex has begun to co-opt all aspects of the natural human bodily life cycle, and all the organ systems within it, as potential targets of medical surveillance and intervention, not excluding the human thyroid. In comparison, 62.4% of female and 37% of male . I have been reading Izabella Wentz. Post by D.ap Tue Feb 21, 2017 6:40 pm "A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and . I wonder if only t3 treatments are preferable than t4 and t3 ? There are several books out there written about the topic. I have so many women friends and family members who have recently been diagnosed with hypothyroidism and their doctors put them all on Synthyroid. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' Thank you for posting it, I agree we all need as much knowledge as we can get! Perhaps she and I could co-author? Methods: The study group included 35 patients (15 women, 20 men, 65.8 7.1 years) with NSCLC in stage IIIB (n = 16, 45.7%) and IV (n = 19,54.3%) who were treated with nivolumab. The Remarkable Heart-Friendy Properties of Avocados. I honestly do not know. 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So I will leave it as a simple thank you for passing this along. Untreated hypothyroidism increases morbidity and mortality. Increased sleepiness. [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. [6] Venditti P, Di Stefano L, Di Meo S: Oxidative stress in cold induced hyperthyroid state. I have posted the link now. [14] In other words, you can normalize the main clinically measurable parameter associated with low thyroid function, i.e. This discussion has been closed to comments. It is very tormenting (for me anyhow) to not know why I got this disease. Just for entertainment value take a look at some more dodgy correlations : I rather liked the correlation between consumption of orange marmalade and birth rate - in the years after the second world war if I remember correctly. If you are already a member, please, Levothyroxine and lung cancer in females: the importance of oxidative stress, recent announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs. Assessment of oxidative stress and its balance has not been taken into consideration up to now as it should be.". Monaldi Arch Chest Dis 2003, 59:140145. hyperthyroidism. millions treated for hypothyroidism at risk for lung cancer. Or that it was the many years of not being diagnosed with hypothyroidism, courtesy of daft blood test ranges, before finally tipping a TSH over 5 (or even 10) before treatment is commenced, by which time the damage is done. This website is for information purposes only. A distorted idea of human nature is sold when people are treated as "the market. Endocrinol. Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. Thanks, I am not suggesting I believe in all that I see. video where the doc is talking about the study , i wlll link study and video below. Sub-laboratory hypothyroidism and the empirical use of Armour thyroid.Altern Med Rev. J Exp Biol 2010, 213:28992911. Physician/Author on Facebook. The Goji Berry: The Jolly Super Food That Gives Yo How to Prevent and Treat Insect Bites Without Hars Supreme Court Rules Drug Companies Exempt From Law Spain Study Confirms Hemp Oil Cures Cancer without Wheatgrass Turns Gray Hair Back to Its Natural Color, Medicinal Cannabis Used To Prevent Cancer Growth. Correlation is not causation. Epub 2013 Mar 28. Whether it should be treated remains controversial. In the U.S., the overall five-year survival rate for patients diagnosed with lung cancer is 25%, which is a 21% improvement over the . Oops, I just saw that I posted the same article. I have no further scientific evidence. 2004 Jun;9(2):157-79. But I for one, do appreciate anything that other members forward about potential links, causes, aids to healing, whatever you can them. This relatively symptom-free reservoir of hypothyroid cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. Is that what releases free radicals? A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. Importance: Whether radioactive iodine (RAI) therapy for hyperthyroidism can increase cancer risk remains a controversial issue in medicine and public health. Here members can share stories, find important information and learn from the experiences of others like themselves. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. Different strokes for different folks for sure! 1). See more of Keri Topouzian, D.O. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. Hypothyroidism can cause depression and, without treatment, the symptoms intensify and directly affect the mental state. With the recent announcement by a National Cancer Institute commissioned expert panel that a variety of so-called 'indolent' neoplasms such as ductal carcinoma in situ (DCIS) and high-grade prostatic intraepithelial neoplasia (HGPIN), formerly understood to be forms of breast and prostate cancers, respectively, should be renamed to reflect their intrinsic benignity, a veritable sea change is occurring within the conventional medical establishment. What I am personally saying issince I personally have a disease that may kill me, I sure as heck have every right to find out ALL I can about it. Correlation is NOT causation. Share your experience, learn from others. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: "[I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. Find how some diseases can be healed with alternative medicine, and share your experience with Biomedicine today is awash in controversy associated with the overdiagnosis and overtreatment of asymptomatic populations. and our Non-small cell lung cancer is the most common type of lung cancer, accounting for about 81% of all cases. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells.