An Med Interna 1995;12(1):33-35. Pharm Biol 2021;59(1):1276-1285. mentioned adverse effects and recurrence rates. View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. There is only one reminder that peony tea contains caffeine. Report of a new case]. View abstract. Some research suggests that licorice extract may help kill bacteria in the mouth that cause tooth decay. A., van der Ven, P. F., Martin, M., Sherman, J., and Haley, J. Prudden JF. View abstract. Bronson Korean Panax Ginseng 1000 mg Supports Energy, Endurance & Vitality + Memory and Mental Performance, 120 Capsules. View abstract. Br J Clin Pharmacol 2008;66:572-4. Yorgun, H., Aksoy, H., Sendur, M. A., Ates, A. H., Kaya, E. B., Aytemir, K., and Oto, A. Brugada syndrome with aborted sudden cardiac death related to liquorice-induced hypokalemia. Z., Zhang, Y. Pakravan F, Salehabad NH, Karimi F, Isfahani MN. View abstract. Not too many side effects of peony tea that we need to worry about. 2019;33(1):117-29. Apparent mineralcorticoid excess syndrome, an often forgotten or unrecognized cause of hypokalemia and hypertension: case report and appraisal of the pathophysiology. Feng Z, Xu J, He G, et al. Crean, A. M., Abdel-Rahman, S. E., and Greenwood, J. P. A sweet tooth as the root cause of cardiac arrest. However, when Angelica Sinensis was tested in combination with products containing other substances, its activity was reduced. Monitor your blood pressure closely. Planta Med 1991;57(2):119-121. Z. In 1977, researchers reported the case of a 58-year-old woman who was eating a whopping 1.8 kilograms (about 63.5 ounces) of black licorice per week and went into cardiac arrest. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Can J Cardiol 2009;25(10):e357-e358. 2019;38(3):657-64. View abstract. J Agric Food Chem 2012;60(36):9062-73. Mol Nutr Food Res 2006;50(11):1080-1086. Clinical trial of deglydyrrhizinized liquorice in gastric ulcer. [Effect of fu-zheng qu-xie on gastric disease infected with Campylobacter pyloridis]. Papandreou V, Magiatis P, Chinou I, et al. Yamaguchi, H., Kidachi, Y., Kamiie, K., Noshita, T., Umetsu, H., and Ryoyama, K. Glycyrrhetinic acid induces anoikis-like death and cytoskeletal disruption in the central nervous system tumorigenic cells. Aging Clin Exp Res. Am J Psychiatry 1994;151:617-8. Migraine. 2020;247:112226. View abstract. The combination alters the Luteinising Hormone vs Follicle Stimulating Hormone ratio that is abnormal in PCOS. View abstract. However, taking too much licorice root may cause side effects. View abstract. van Beers, E. J., Stam, J., and van den Bergh, W. M. Licorice consumption as a cause of posterior reversible encephalopathy syndrome: a case report. Clin Neurol Neurosurg 1993;95(1):35-37. Licorice roots can be consumed directly to get relief from cough and sore throat. Farese RV Jr, Biglieri EG, Shackleton CH, et al. A randomized, double-blind comparison of licorice versus sugar-water gargle for prevention of postoperative sore throat and postextubation coughing. Researchers from the University of Minnesota studied 50 atopic dogs in a randomized, double-blind, placebo-controlled trial. Neth J Med 2005;63:119-20. Biomed.Chromatogr. J Biol Response Mod 1985;4:551-84. Effects of cerebral ischemia-reperfusion on pharmacokinetic fate of paeoniflorin after intravenous administration of Paeoniae Radix extract in rats. Botanical names: Paeonia lactiflora, Paeonia suffruticosa, Paeonia veitchii How It Works Peony contains a unique glycoside called paeoniflorin. Licorice root is aromatic and is used as a flavoring agent in tea and other beverages. Volatiles with antimicrobial activity from the roots of Greek Paeonia taxa. Koster, M. and David, G. K. Reversible severe hypertension due to licorice ingestion. View abstract. Association of emblica, licorice and belides as an alternative to hydroquinone in the clinical treatment of melasma. View abstract. Bannister, B., Ginsburg, R., and Shneerson, J. Cardiac arrest due to liquoriceinduced hypokalaemia. Zhong.Xi.Yi.Jie.He.Za Zhi. View abstract. Clin Rheumatol. Kumada T, et al. Scali, M., Pratesi, C., Zennaro, M. C., Zampollo, V., and Armanini, D. Pseudohyperaldosteronism from liquorice-containing laxatives. Other side effects of licorice use include . View abstract. View abstract. Pharmazie 2010;65(8):624-8. View abstract. A., Lee, S. H., and Lee, S. M. Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice. View abstract. Yuan, H. N., Wang, C. Y., Sze, C. W., Tong, Y., Tan, Q. R., Feng, X. J., Liu, R. M., Zhang, J. Pulmonary edema following a licorice binge. An unusual cause of hypokalemic paralysis: chronic licorice ingestion. View abstract. View abstract. Licorice is believed to have anti-androgenic effects, meaning that it may be active to reduce testosterone levels. The effects of dietary licorice flavonoid oil supplementation on body balance control in healthy middle-aged and older Japanese women undergoing a physical exercise intervention: a randomized, double-blind, placebo-controlled trial. View abstract. Journal of Clinical Therapeutics Medicine. View abstract. Tewari SN, Wilson AK. Cancer Lett. Life Sci 9-27-2002;71(19):2267-2277. Cureus 2020;12(11):e11656. Hyodo T, Taira T, Kumakura M, et al. therapy. Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: a randomized controlled study. Peony-glycyrrhiza decoction for antipsychotic-related hyperprolactinemia in women with schizophrenia: a randomized controlled trial. Case Rep Emerg Med. Exploring Pseudohyperaldosteronism in Glycyrrhizic Acid Toxicity From Chronic Licorice Root Consumption. Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses. Caradonna, P., Gentiloni, N., Servidei, S., Perrone, G. A., Greco, A. V., and Russo, M. A. View abstract. View abstract. van der Zwan A. Ngan LT, Moon JK, Shibamoto T, Ahn YJ. 2005;25(6):540-542. Nephron 2002;90:240. Licorice might change how quickly the liver breaks down these medications. Licorice, tobacco chewing, and hypertension. View abstract. Phytother Res. All rights reserved. View abstract. View abstract. Lozenge-induced hypermineralcorticoid state--a unique case of licorice lozenges resulting in hypertension and hypokalemia. Fiore, C., Eisenhut, M., Krausse, R., Ragazzi, E., Pellati, D., Armanini, D., and Bielenberg, J. Antiviral effects of Glycyrrhiza species. Indian J Dent Res 2010;21(3):380-384. Int Immunopharmacol. This might decrease the effects of midazolam. World J Gastroenterol 2005;11:2124-9. . Gupta D, Agrawal S, Sharma JP. The author has contributed to research in topic(s): Rheum officinale. Am J Chin Med 2001;29(3-4):459-467. Comparative Study of the Effect of Licorice Muco-adhesive Film on Radiotherapy Induced Oral Mucositis, A Randomized Controlled Clinical Trial. Altern Med Rev 1999;4(3):178-188. Information from this source is evidence-based and objective, and without commercial influence. Purnak, T., Ozaslan, E., Beyazit, Y., and Haznedaroglu, I. C. Upper gastrointestinal bleeding in a patient with defective hemostasis successfully treated with ankaferd blood stopper. Lipids Health Dis 2011;10:29. The dose of your warfarin might need to be changed. View abstract. Little is known about whether it's safe to use licorice root while breastfeeding. View abstract. QJM 2011;104(12):1093-1095. View abstract. Ai, M., Yamaguchi, T., Odaka, T., Mitsuhashi, K., Shishido, T., Yan, J., Seza, A., and Saisho, H. Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy. Postgrad Med 2017;129(3):329-31. View abstract. Quinkler M, Stewart PM. Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells. Erratum in: Clin Rheumatol. Chang GH, Lin YS, Hsu KH, et al. View abstract. Phytother Res 2008;22(2):141-148. View abstract. Taking licorice and loop diuretics together might make potassium levels drop too low. This information may not fit your specific health circumstances. Liang, R. N., Liu, J., and Lu, J. Deglycyrrhizinated liquorice in aphthous ulcers. J Clin Psychopharmacol 2008;28(3):264-370. That's because licorice real black licorice, not the phony licorice-flavored stuff flavored with anise oil . 17. J Cancer Res Ther. Francini-Pesenti F, Puato M, Piccoli A, Brocadello F. Liquorice-induced hypokalaemia and water retention in the absence of hypertension. Costa, A., Moises, T. A., Cordero, T., Alves, C. R., and Marmirori, J. View abstract. Taking licorice along with estrogen might decrease the effects of estrogen. Yoshida S, Takayama Y. Licorice-induced hypokalemia as a treatable cause of dropped head syndrome. Minerva Med 2008;99(1):91-94. Cisplatin is used to treat cancer. Phytomedicine 2003;10:271-85. Bardhan, K. D., Cumberland, D. C., Dixon, R. A., and Holdsworth, C. D. Clinical trial of deglycyrrhizinised liquorice in gastric ulcer. Bocker, D. and Breithardt, G. [Induction of arrhythmia by licorice abuse]. Mechanisms by which Hange-shashin-to reduces prostaglandin E2 levels. J Altern Complement Med 2009;15(4):439-443. Endocrinol Jpn 1991;38(2):167-174. Paeoniflorin, a constituent of white peony root, has demonstrated inhibition of testosterone synthesis in vitro, without affecting estradiol synthesis.It reduces testosterone production by the ovaries but not the adrenal glands. MacKenzie, M. A., Hoefnagels, W. H., Jansen, R. W., Benraad, T. J., and Kloppenborg, P. W. The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers. Am J Epidemiol 2001;153:1085-8. Kormann R, Languille E, Amiot HM, Hertig A. Lee, C. K., Park, K. K., Lim, S. S., Park, J. H., and Chung, W. Y. Tamir S, Eizenberg M, Somjen D, et al. View abstract. Hasegawa, J., Suyama, Y., Kinugawa, T., Morisawa, T., and Kishimoto, Y. Echocardiographic findings of the heart resembling dilated cardiomyopathy during hypokalemic myopathy due to licorice-induced pseudoaldosteronism. View abstract. Fugh-Berman, A. Herb-drug interactions. It has an effect similar to aldosterone. Roussak NJ. View abstract. Jia, Y. Exp Ther Med 2016;11(3):1135-41. Zhu Q, Qi X, Wu Y, Wang K. Clinical study of total glucosides of paeony for the treatment of diabetic kidney disease in patients with diabetes mellitus. About Dr.Cope. Iran J Pharm Res 2012;11(2):541-8. J Nutr Sci Vitaminol. Gardner Z, McGuffin M. Boca Raton, FL: CRC Press, 2013. Hum.Exp Toxicol. Cardiovasc.Drugs Ther 1998;12(6):599-600. View abstract. Dong quai grows at high altitudes in the cold, damp, mountains of China, Korea, and Japan. View abstract. Some believe it may also increase estrogen and prolactin levels in women, though more research is warranted. Anon. Strandberg TE, Andersson S, Jarvenpaa AL, et al. View abstract. They also have a range of other intriguing activities. Vestn.Dermatol.Venerol. Am J Chin Med 2003;31:445-53. . Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial. 83rd Annual Meeting of the Endocrine Society, June 20-23 2001;abstract P1-573. Therapeutic Research Faculty 2020. . Effects of Paeoniae Radix, a traditional Chinese medicine, on the pharmacokinetics of phenytoin. 1988;8(11):660-2, 645. Sheth, V. M. and Pandya, A. G. Melasma: a comprehensive update: part II. Biofactors 2009;35(1):98-104. 2011;25(2):312-313. Chamberlain, J. J. and Abolnik, I. View abstract. Effect of Shakuyaku-kanzo-to (Tsumura TJ-68) on muscle cramps accompanying cirrhosis in a placebo-controlled double-blind parallel study. View abstract. Zhongguo Zhong.Xi.Yi Jie.He.Za Zhi 2008;28(12):1090-1092. View abstract. Drug Metab Dispos 2015;43(7):1147-53. Licorice that has the active ingredient of glycyrrhiza can have serious side effects. Adjuvant role of a new emollient cream in patients with palmar and/or plantar psoriasis: a pilot randomized open-label study. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Asian Medical Journal 1984;26(7):423-438. Anti Erection Pill. J Intern Med 1999;245:307-10. [Comparison of pre- and post-treatmental hepatohistology with heavy dosage of Paeonia rubra on chronic active hepatitis caused liver fibrosis]. Am J Chin Med 1996;24:165-8. Kang, J. H., Park, Y. H., Choi, S. W., Yang, E. K., and Lee, W. J. Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells. Sakamoto, S., Yoshino, H., Shirahata, Y., Shimodairo, K., and Okamoto, R. Pharmacotherapeutic effects of kuei-chih-fu-ling-wan (keishi-bukuryo-gan) on human uterine myomas. Dying for a cup of tea. View abstract. Agarwal, A., Gupta, D., Yadav, G., Goyal, P., Singh, P. K., and Singh, U. Oh, G. S., Pae, H. O., Oh, H., Hong, S. G., Kim, I. K., Chai, K. Y., Yun, Y. G., Kwon, T. O., and Chung, H. T. In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on human hepatocellular carcinoma cell line, SK-HEP-1 cells. Sheehan M, Rustin MHA, Atherton DJ, et al. Effects of low-dose liquorice alone or in combination with hydrochlorothiazide on the plasma potassium in healthy volunteers. View abstract. 2020;16(3):458-462. Migraine is a type of headache. Nat Prod Res 2007;21(14):1234-1241. View abstract. Hsiang, C. Y., Hsieh, C. L., Wu, S. L., Lai, I. L., and Ho, T. Y. Inhibitory effect of anti-pyretic and anti-inflammatory herbs on herpes simplex virus replication. Hyodo T, Taira T, Kumakura M, et al. The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae Radix. Neurology 2010;75(21):1939-1941. CJEM 2010;12(3):224-225. Neth J Med 2005;63:149-50. Licorice root contains glycyrrhizin, which can cause side effects when eaten in large amounts. Yamada, K., Kanba, S., Yagi, G., and Asai, M. Effectiveness of herbal medicine (shakuyaku-kanzo-to) for neuroleptic-induced hyperprolactinemia. Leem, K., Kim, H., Boo, Y., Lee, H. S., Kim, J. S., Yoo, Y. C., Ahn, H. J., Park, H. J., Seo, J. C., Kim, H. K., Jin, S. Y., Park, H. K., Chung, J. H., and Cho, J. J. Learn more about Peony health benefits, uses, side effects, effectiveness, safety, precautions, and warnings. Sakamoto S, Kudo H, Suzuki S, et al. View abstract. Motherwort, Peony, Dong Quai, Lady's Mantle, Licorice, and Rose, Fennel, Alfalfa. Nephron 2002;90:240. Licorice. View abstract. View abstract. This can increase the effects and side effects of corticosteroids. Exp.Mol.Med 12-31-2003;35(6):467-474. BMJ Case Rep. 2013 Sep 19;2013. The effect of Glycyrrhiza glabra L. on primary dysmenorrhea compared with ibuprofen: A randomized, triple-blind controlled trial. Select a condition to view a list of vitamins. View abstract. Diane Calello, executive medical director of the New Jersey Poison Control Center, based at Rutgers New Jersey Medical School, discusses safe . Monograph. J Hum Hypertens 2001;15:549-52. View abstract. J Ethnopharmacol 2021;275:114116. Common side effects of licorice include: Absence of a menstrual period . But I didn't take it long enough to see any change. Evid Based Complement Alternat Med. View abstract. View abstract. Read more. Peony might have some of the same effects as estrogen. View abstract. View abstract. Epilepsy Res 2021;176:106735. View abstract. CJEM 2009;11(1):94-96. View abstract. Rees, W. D., Rhodes, J., Wright, J. E., Stamford, L. F., and Bennett, A. Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats. This could change the effects and side effects of these medications. . Immediately afterwards, Teacher Liu looked at her, picked up her paper, and said, Student Zhou Xiaotong, this time I ll give you a warning. A Rutgers expert discusses how eating black licorice can affect your health. J Endocrinol Invest 2003;26:646-50. Total glucosides of peony ameliorates Sjogren's syndrome by affecting Th1/Th2 cytokine balance. Previous studies have estimated that a dose of 1 to 5 grams (g) of licorice root daily is safe for most adults. Side effects, toxicity, and interactions. Phytother.Res 2004;18(3):241-243. Peony might have some of the same effects as estrogen. Arase, Y., Ikeda, K., Murashima, N., Chayama, K., Tsubota, A., Koida, I., Suzuki, Y., Saitoh, S., Kobayashi, M., and Kumada, H. The long term efficacy of glycyrrhizin in chronic hepatitis C patients. Huang, W. W., Wang, M. Y., Shi, H. M., Peng, Y., Peng, C. S., Zhang, M., Li, Y., Lu, J., and Li, X. Yoon JY, Cha JM, Hong SS, et al. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. A., Keller, W. J., Pereira, M. A., and Kinghorn, A. D. Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). Ultrastruct Pathol 1992;16(5):529-535. Jin, C. Y., Wang, D. L., and Fang, Z. D. [Effect of integrative Chinese and Western medicine in treating chronic urticaria and its impact on interleukin-10 and interleukin-8 in peripheral blood]. BJU Int 2000;85:481-5. Teelucksingh S, Mackie AD, Burt D, McIntyre MA, Brett L, Edwards CR. View abstract. View abstract. A pilot study. Brush, J., Mendenhall, E., Guggenheim, A., Chan, T., Connelly, E., Soumyanath, A., Buresh, R., Barrett, R., and Zwickey, H. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. View abstract. View abstract. Zhang XH, Lowe D, Giles P, et al. Nishioka, K. and Seguchi, T. Contact allergy due to oil-soluble licorice extracts in cosmetic products. Removes excess melanin: Licorice extract brightens the skin in another way, too. N Engl J Med 1999;341:1158. Another type of licorice, called DGL or deglycyrrhizinated licorice, does not seem to have the same side effects and is sometimes used to treat peptic ulcers, canker sores, and reflux (GERD). Some research studies have found Angelica Sinensis to be beneficial for its effects on some symptoms of menopause. View abstract. [Clinical study on treatment of mid-advanced crescentic nephritis by qingre huoxue recipe]. Astragalus may be safe when used orally and appropriately. Liquorice and hypertension. Licorice consumption and serum testosterone in healthy man. Medicine (Baltimore) 2018;97(11):e0073. is tatcha violet c brightening serum safe for pregnancy is tatcha violet c brightening serum safe for pregnancy View abstract. 1999;15:499-523. Int J Dermatol 1999;38:387-92 . 2 in the perioperative stage of laparoscopic cholecystectomy]. Early evidence suggests that taking 45 grams of a specific product containing peony and licorice (Peony-Glycyrrhiza Decoction, PGD) daily for 4 weeks reduces levels of a hormone called prolactin in women with high levels of prolactin, without affecting other hormone levels or mental symptoms. Licorice seems to change hormone levels in the body. Phytother Res 2012;26(9):1381-1384. Gibertoni, M., Bonito, V., Colombo, A., Falasca, A., and Nichelli, P. [Licorice-induced myopathy. Evid Based Complement Alternat Med 2016;2016:8292486. View abstract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. View abstract. Report of 2 cases and review of the literature. Grebeniuk, V. N., Mannanov, A. M., Korsun, V. F., and Vinogradova, A. I. View abstract. Traditionally, white peony root is used for treating a wide range of health ailments, like inflammation, pain, and many more. Effects of chalcones isolated from licorice roots on leukotriene biosynthesis in human polymorphonuclear neutrophils. View abstract. Pak J Med Sci 2022;38(1):271-275. Liu J. Br Med J 9-17-1977;2(6089):738-739. View abstract. Eur J Dermatol. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11. Tacconi, P., Paribello, A., Cannas, A., and Marrosu, M. G. Carpal tunnel syndrome triggered by excessive licorice consumption. View abstract. View abstract. 2019;35:329-41. BMJ 1997;314:731-2. View abstract. View abstract. Patel P, Aknouk M, Dawson A, et al. Du, J. H. and Dong, B. D. [Comparative study on clinical efficacy of using methotrexate singly or combined with total glucosides of Paeony in treating rheumatoid arthritis]. Medicine (Baltimore) 2019;98(35):e16601. It may disrupt the production of sex hormones ( 9 ). Int J Cardiol 2008;124(3):e42-e44. J Ethnopharmacol 2002;81:101-4.. View abstract. Anesth Analg. View abstract. Werner, S., Brismar, K., and Olsson, S. Hyperprolactinaemia and liquorice. View abstract. Features : Herbal Energy & Performance: Bronson's Korean Panax Ginseng provides 1000 MG per serving to naturally support energy and physical performance without any unwanted jitters. Sheehan MP, Atherton DJ. Celery juice has become very popular now as it is believed to cure many health problems including obesity, thyroid, gout, blood pressure and fluid retention. Assessment of the therapeutic effect of total glycosides of peony for juvenile idiopathic arthritis: a systematic review and meta-analysis. View abstract. Chen, M. F., Shimada, F., Kato, H., Yano, S., and Kanaoka, M. Effect of oral administration of glycyrrhizin on the pharmacokinetics of prednisolone. Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Holtmann G, Madisch A, Juergen H, et al. Foster CA, Church KS, Poddar M, Van Uum SH, Spaic T. Licorice-induced hypertension: a case of pseudohyperaldosteronism due to jelly bean ingestion. (Glycyrrhiza glabra), it performs better, especially for relaxing muscles, reducing painful menstruation, as well as lowering serum and free testosterone levels in women with PCOS.